Bioinformatics

Learning WES Data Analysis 4

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Learning WES Data Analysis 4

SnpEff: Mutation Site Annotation Reference tutorial: https://www.jianshu.com/p/ad1ab3d7fcd0 SnpEff download link: http://snpeff.sourceforge.net/download.html Download and Install Software $ wget -c http://sourceforge.net/projects/snpeff/files/snpEff_latest_core.zip $ unzip snpEff_latest_core.zip Check the installation status: (wes) root@1100150:~/wes_cancer/biosoft# ll total 607405 drwxr-xr-x 6 root root 9 Jun 27 01:04 ./ drwxr-xr-x 5 root root 5 Jun 18 08:37 ../ drwxr-xr-x 4 1002 jmzeng 19 Jun … Read more

Comprehensive Analysis of OSCSRDEGs in TNBC

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Comprehensive Analysis of OSCSRDEGs in TNBC

Research and Development Ideas Here is a preparation by Xiaosen Document Contribution File Case Title: Comprehensive Analysis of Genes Related to Oxidative Stress and Cellular Senescence in Triple-Negative Breast Cancer Published Journal: Heliyon Publication Date: 2024-07-16 Impact Factor: 3.4 [Background] Oxidative stress and cellular senescence (OSCS) significantly impact the occurrence and progression of triple-negative breast … Read more

Key Gene Screening and Validation in Non-Tumor Bioinformatics

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Key Gene Screening and Validation in Non-Tumor Bioinformatics

Impact Factor: 7.7 Research Overview: Pulmonary hypertension (PH) is a heterogeneous group of diseases defined as a mean pulmonary artery pressure ≥20 mmHg measured during right heart catheterization at rest. Pulmonary arterial hypertension (PAH) is one of the main subtypes of PH, characterized by pulmonary vascular remodeling mediated by excessive proliferation of pulmonary artery smooth … Read more

Integrating Bioinformatics and Machine Learning to Unveil Lactate Metabolism and Rheumatoid Arthritis Connection

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Integrating Bioinformatics and Machine Learning to Unveil Lactate Metabolism and Rheumatoid Arthritis Connection

Today, I will analyze an article published in April 2024 in Sci Rep (IF:4.0) titled “Unveiling the link between lactate metabolism and rheumatoid arthritis through integration of bioinformatics and machine learning“. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis and joint damage. Recent research findings suggest a potential link with abnormal lactate … Read more