With the continuous development of genetics, breeding, and the increasing advancements in the Human Genome Project and molecular biology, biological data has experienced explosive growth over just a few decades. For example, algorithms such as regression analysis, random forests, and support vector machines in bioinformatics are already quite mature. Recently, while reading literature, I came … Read more
A Powerful Tool in Kaggle: The XGBoost Algorithm Hi, everyone, I am Chenxi. This article is also based on a request from a friend who has been pushed by their boss to build a model, so they reached out to me for some guidance. Student A: Chenxi, Ionly know R, is there a model that … Read more
1 What Is Artificial Intelligence Artificial Intelligence (AI) has many definitions. One definition of AI is: “Artificial intelligence is a science and a set of computational techniques inspired by how humans use their nervous systems and bodily perceptions to learn, reason, and take action, but is often fundamentally different from these techniques. AI can be … Read more
This issue uses cursor to solve the problems encountered in learning basic skills in bioinformatics. Cursor is a code editor based on ChatGPT4, which can significantly shorten the learning cycle if used correctly. The following records the problem-solving process, and the code included in the article is from Chapter 3 of ‘Practical R Programming’. Problem … Read more
———————————— Exclusive arrangement, unauthorized use will be pursued In life science research, the interaction between proteins and nucleic acids plays a crucial role. Accurately predicting nucleic acid binding sites on protein surfaces is significant for understanding life regulatory mechanisms and developing new drugs. Recently, a research team from the University of Hong Kong and ShanghaiTech … Read more
SnpEff: Mutation Site Annotation Reference tutorial: https://www.jianshu.com/p/ad1ab3d7fcd0 SnpEff download link: http://snpeff.sourceforge.net/download.html Download and Install Software $ wget -c http://sourceforge.net/projects/snpeff/files/snpEff_latest_core.zip $ unzip snpEff_latest_core.zip Check the installation status: (wes) root@1100150:~/wes_cancer/biosoft# ll total 607405 drwxr-xr-x 6 root root 9 Jun 27 01:04 ./ drwxr-xr-x 5 root root 5 Jun 18 08:37 ../ drwxr-xr-x 4 1002 jmzeng 19 Jun … Read more
Research and Development Ideas Here is a preparation by Xiaosen Document Contribution File Case Title: Comprehensive Analysis of Genes Related to Oxidative Stress and Cellular Senescence in Triple-Negative Breast Cancer Published Journal: Heliyon Publication Date: 2024-07-16 Impact Factor: 3.4 [Background] Oxidative stress and cellular senescence (OSCS) significantly impact the occurrence and progression of triple-negative breast … Read more
Impact Factor: 7.7 Research Overview: Pulmonary hypertension (PH) is a heterogeneous group of diseases defined as a mean pulmonary artery pressure ≥20 mmHg measured during right heart catheterization at rest. Pulmonary arterial hypertension (PAH) is one of the main subtypes of PH, characterized by pulmonary vascular remodeling mediated by excessive proliferation of pulmonary artery smooth … Read more
Today, I will analyze an article published in April 2024 in Sci Rep (IF:4.0) titled “Unveiling the link between lactate metabolism and rheumatoid arthritis through integration of bioinformatics and machine learning“. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis and joint damage. Recent research findings suggest a potential link with abnormal lactate … Read more