How to Use MCPcounter for Immune Infiltration Analysis

How to Use MCPcounter for Immune Infiltration Analysis

MCPcounter Hello everyone, welcome to Xiaoyang’s column! In previous posts, we introduced ssGSEA, which stands for single-sample Gene Set Enrichment Analysis, an extension of the GSEA method designed for situations where GSEA cannot be performed on a single sample. Interested friends can check it out in Xiaoyang’s column. Today, I will introduce a method for … Read more

Key Gene Screening and Validation in Non-Tumor Bioinformatics

Key Gene Screening and Validation in Non-Tumor Bioinformatics

Impact Factor: 7.7 Research Overview: Pulmonary hypertension (PH) is a heterogeneous group of diseases defined as a mean pulmonary artery pressure ≥20 mmHg measured during right heart catheterization at rest. Pulmonary arterial hypertension (PAH) is one of the main subtypes of PH, characterized by pulmonary vascular remodeling mediated by excessive proliferation of pulmonary artery smooth … Read more

Integrating Bioinformatics and Machine Learning to Unveil Lactate Metabolism and Rheumatoid Arthritis Connection

Integrating Bioinformatics and Machine Learning to Unveil Lactate Metabolism and Rheumatoid Arthritis Connection

Today, I will analyze an article published in April 2024 in Sci Rep (IF:4.0) titled “Unveiling the link between lactate metabolism and rheumatoid arthritis through integration of bioinformatics and machine learning“. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis and joint damage. Recent research findings suggest a potential link with abnormal lactate … Read more