Introduction DNA damage promotes hematopoietic stem cell (HSC) aging, but the underlying molecular mechanisms are not fully understood. On April 17, 2024, the team led by Wang Jianwei from the Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences), with Dr. He Hanqing as the first author, published … Read more
Smooth muscle cells (SMCs) in atherosclerotic plaques exhibit various non-classical phenotypes, which may affect plaque stability, leading to the potential for myocardial infarction or stroke. It is currently believed that different SMC phenotypes play either beneficial or detrimental roles in the pathogenesis of atherosclerotic lesions. The classical view that SMCs promote plaque stability has been … Read more
Click the above“Good Medicine”, follow us Introduction The metacarpophalangeal joint primarily performs flexion and extension, with a few individuals able to hyperextend. The degree of flexion varies significantly. The metacarpophalangeal joint often dislocates due to external forces caused by finger sprains, punctures, or extreme dorsal extension or flexion. Depending on the position of the finger … Read more
Kiwi Kiwi is a nutrient-rich fruit, one of the few varieties that remain bright green after ripening, with this green color coming from chlorophyll (Chl). During the storage of kiwi, Chl is quite unstable and easily degrades, leading to discoloration, which is accompanied by the ripening and senescence of the kiwi fruit. Therefore, it is … Read more
Click the blue text to follow us Liver fibrosis is a common sequel of various chronic liver injuries, characterized by the excessive accumulation of extracellular matrix (ECM) proteins such as type I collagen and fibronectin. The persistence of the fibrotic process often leads to cirrhosis and hepatocellular carcinoma (HCC). The hallmark of liver fibrosis is … Read more
This article is prohibited from being reproduced without authorization. Following the previous article: Latest review: Various traumatic anatomy and MRI reading techniques of the wrist, packed with useful information! Abstract The anatomy of the wrist and hand is complex, containing many small structures. Magnetic Resonance Imaging (MRI) is the ideal imaging modality for assessing various … Read more
Abstract Objective: To explore the correlation between monocyte chemoattractant protein-1 (MCP-1) and its gene polymorphisms with diabetic peripheral neuropathy (DPN) in Han Chinese population in the coastal area of Zhejiang province. Methods: General data and blood samples were collected from 187 hospitalized type 2 diabetes patients in the endocrinology department of the First People’s Hospital … Read more
Written by | November Edited by | Xi Imaging of mRNA typically utilizes a method involving fluorescent proteins. For instance, green fluorescent protein is fused with the MS2 phage coat protein (MCP), forming MCP-GFP, which can be recruited to mRNA containing 24-48 consecutive MS2 hairpin structures in the 3′ UTR region【1】. This system is known … Read more
First Author: Zhu Huaxin, Hao Zheng Corresponding Author: Li Meihua Affiliation: Department of Neurosurgery, First Affiliated Hospital of Nanchang University [REF: Zhu H, Hao Z, Xing Z, Tan J, Zhao Y, Li M. Impinging Flow Induces Expression of Monocyte Chemoattractant Protein-1 in Endothelial Cells Through Activation of the c-Jun N-terminal Kinase/c-Jun/p38/c-Fos Pathway [published online ahead … Read more
Cyclin-dependent kinase 1 (CDK1) plays a crucial role in various mitotic processes such as cytoskeletal reorganization, chromosome segregation, and cytokinesis. It is an essential regulatory factor. CDK1 is expressed stably throughout the cell cycle, and its activity is closely related to cyclin A and cyclin B, while being regulated by many post-translational modifications (PTMs), with … Read more