CD45-ADC Transplant Corrects Rag1 Immunodeficiency
CD45-ADC transplantation corrects Rag1 immunodeficiency in congenic and haploidentical settings. Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings. For patients with mutations in recombination activating gene 1 (RAG1), hematopoietic cell transplantation is a potentially curative option, but complications can be severe. Could conditioning with CD45 antibody-drug conjugates provide a promising approach? Below … Read more