RAG1

CD45-ADC Transplant Corrects Rag1 Immunodeficiency

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CD45-ADC Transplant Corrects Rag1 Immunodeficiency

CD45-ADC transplantation corrects Rag1 immunodeficiency in congenic and haploidentical settings. Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings. For patients with mutations in recombination activating gene 1 (RAG1), hematopoietic cell transplantation is a potentially curative option, but complications can be severe. Could conditioning with CD45 antibody-drug conjugates provide a promising approach? Below … Read more

Case Report: Hemophagocytic Lymphohistiocytosis with Rag1 Gene Mutation

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Case Report: Hemophagocytic Lymphohistiocytosis with Rag1 Gene Mutation

Authors: Zhao Xiaoyu, Jiang Nan, Liu Chunyan, Fu Rong Author Affiliation: Department of Hematology, Tianjin Medical University General Hospital Corresponding Author: Fu Rong, [email protected] Funding: National Natural Science Foundation (81870101, 81970115) Citation Format: Zhao Xiaoyu, Jiang Nan, Liu Chunyan, et al. Case Report: Hemophagocytic Lymphohistiocytosis with Rag1 Gene Mutation [DB/OL]. China Clinical Case Achievement Database, … Read more

Severe Combined Immunodeficiency (RAG Deficiency) Case Study

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Severe Combined Immunodeficiency (RAG Deficiency) Case Study

Severe combined immunodeficiency (Severe combined immunodeficiency, SCID) is a class of diseases characterized by severe defects in both humoral and cellular immunity, generally with a more prominent T-cell immunodeficiency. It is a rare hereditary primary immunodeficiency disease.SCID is usually inherited in an autosomal recessive or X-linked manner, with some sporadic cases. About 50% of SCID … Read more