CD45-ADC transplantation corrects Rag1 immunodeficiency in congenic and haploidentical settings.
Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings.
For patients with mutations in recombination activating gene 1 (RAG1), hematopoietic cell transplantation is a potentially curative option, but complications can be severe. Could conditioning with CD45 antibody-drug conjugates provide a promising approach? Below is a brief report from Pala et al., with data derived from mouse models.
(J Allergy Clin Immunol 2024; 153(1):341-348.e3) https://bit.ly/3HmvjjC
(Translated by Song Jing, edited by Zhang Wei)
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