Immunodeficiency

CD45-ADC Transplant Corrects Rag1 Immunodeficiency

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CD45-ADC Transplant Corrects Rag1 Immunodeficiency

CD45-ADC transplantation corrects Rag1 immunodeficiency in congenic and haploidentical settings. Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings. For patients with mutations in recombination activating gene 1 (RAG1), hematopoietic cell transplantation is a potentially curative option, but complications can be severe. Could conditioning with CD45 antibody-drug conjugates provide a promising approach? Below … Read more

Severe Combined Immunodeficiency (RAG Deficiency) Case Study

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Severe Combined Immunodeficiency (RAG Deficiency) Case Study

Severe combined immunodeficiency (Severe combined immunodeficiency, SCID) is a class of diseases characterized by severe defects in both humoral and cellular immunity, generally with a more prominent T-cell immunodeficiency. It is a rare hereditary primary immunodeficiency disease.SCID is usually inherited in an autosomal recessive or X-linked manner, with some sporadic cases. About 50% of SCID … Read more