Introduction Immune inhibitory receptors (IRs) play a significant role in regulating the innate and adaptive immunity during chronic viral infections and cancer. Under chronic antigen stimulation, T cell dysfunction or exhaustion occurs, leading to the upregulation of many IRs, including programmed cell death receptor 1 (PD-1) and T cell immunoreceptor with immunoglobulin and ITIM domains … Read more
Based on clinical research progress Keeping up with academic literature reports Inviting authoritative experts for interpretation “China Medical Forum” collaborates with “Baiyi Medical Department“ Monthly selection, classic every issue Sincerely invite attention to “Frontline of Immunotherapy for Gastrointestinal Cancer!“ Reviewing Experts Professor Xu Tongpeng MD, Associate Chief Physician of Oncology at Jiangsu Provincial People’s Hospital, … Read more
Click the blue text Follow us /Abstract/ Background Macrophages are the most common infiltrating immune cells in gliomas, exhibiting various pro-tumor and anti-tumor effects. However, the different subpopulations of macrophages and their impact on the tumor microenvironment remain unclear. Methods We combined new and previously published single-cell RNA sequencing data from 66 gliomas, analyzing 19,331 … Read more
When mentioning Merkel cell carcinoma, some colleagues may assume that this tumor originates from the Merkel cells of the epidermis. In fact, the reason it is named Merkel cell carcinoma is that the tumor cells are morphologically, immunophenotypically, and ultrastructurally similar to normal Merkel cells, and do not originate from them! Merkel cell carcinoma (MCC) … Read more
Introduction Immunotherapy is used to treat almost all patients with advanced non-small cell lung cancer (NSCLC); however, identifying robust predictive biomarkers remains challenging. Here, the authors demonstrate the ability to integrate medical imaging, histopathology, and genomic features to predict immunotherapy response, using a cohort of 247 patients with advanced NSCLC who obtained multimodal baseline data … Read more
The text contains 2078 words and 5 images. Estimated reading time: 8 minutes The concept of “magic bullet” targeted therapy was proposed as early as the early 20th century. With the advent of hybridoma technology and the development of humanized monoclonal antibody technology, breakthroughs have been made in the research and development of ADC drugs. … Read more