Immune Checkpoint Inhibitors: TIGIT
Introduction Immune inhibitory receptors (IRs) play a significant role in regulating the innate and adaptive immunity during chronic viral infections and cancer. Under chronic antigen stimulation, T cell dysfunction or exhaustion occurs, leading to the upregulation of many IRs, including programmed cell death receptor 1 (PD-1) and T cell immunoreceptor with immunoglobulin and ITIM domains … Read more
