Rag GTPase

mTORC1 Regulation Logic Gates Explored

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mTORC1 Regulation Logic Gates Explored

Written by丨Enzyme Beauty The mTORC1 complex is the switch for cellular anabolic metabolism, sensing and integrating the effects of cellular energy, nutrient levels, and growth factor stimulation to promote cell growth while inhibiting catabolism. Under nutrient-rich conditions, the Ragulator-Rag GTPase is responsible for recruiting mTORC1 to the surface of lysosomes, the organelles that execute the … Read more

Amino Acids Regulate mTORC1 Activity Through Rag GTPase Dimer

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Amino Acids Regulate mTORC1 Activity Through Rag GTPase Dimer

Actually, I rarely read such purely mechanistic articles, but since mTORC1 is a classic signaling pathway, some newly discovered mechanisms may still be helpful for future explorations. The mTOR signaling pathway is recognized as a target of rapamycin, and my main focus is on adaptive immunity. In recent years, a group of scientists led by … Read more