lysosome

GPR137B Regulates Rag GTPase and mTORC1 Activity

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GPR137B Regulates Rag GTPase and mTORC1 Activity

Editor | Enzyme Beauty The lysosome is an organelle responsible for the degradation and recycling of materials within the cell, playing a key role in organism development, metabolic balance, and the maintenance of cellular homeostasis. Centered around the lysosome, the cell has structured a system that integrates responses to external stress, amino acid metabolism, and … Read more

mTORC1 Regulation Logic Gates Explored

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mTORC1 Regulation Logic Gates Explored

Written by丨Enzyme Beauty The mTORC1 complex is the switch for cellular anabolic metabolism, sensing and integrating the effects of cellular energy, nutrient levels, and growth factor stimulation to promote cell growth while inhibiting catabolism. Under nutrient-rich conditions, the Ragulator-Rag GTPase is responsible for recruiting mTORC1 to the surface of lysosomes, the organelles that execute the … Read more