mTORC1 Regulation Logic Gates Explored
Written by丨Enzyme Beauty The mTORC1 complex is the switch for cellular anabolic metabolism, sensing and integrating the effects of cellular energy, nutrient levels, and growth factor stimulation to promote cell growth while inhibiting catabolism. Under nutrient-rich conditions, the Ragulator-Rag GTPase is responsible for recruiting mTORC1 to the surface of lysosomes, the organelles that execute the … Read more