TFEB

Nature | Analysis of mTORC1-TFEB-Rag-Ragulator Complex Structure

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Editor | XiThe decision of whether a cell initiates autophagy is crucial. When nutrients are abundant, cells reduce catabolism by inhibiting the synthesis of lysosomes. Lysosomes are organelles responsible for the degradation and recycling of cellular components. The formation of lysosomes is regulated by the transcription factor TFEB. When cells have sufficient nutrients and do … Read more

mTORC1 Regulation Logic Gates Explored

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mTORC1 Regulation Logic Gates Explored

Written by丨Enzyme Beauty The mTORC1 complex is the switch for cellular anabolic metabolism, sensing and integrating the effects of cellular energy, nutrient levels, and growth factor stimulation to promote cell growth while inhibiting catabolism. Under nutrient-rich conditions, the Ragulator-Rag GTPase is responsible for recruiting mTORC1 to the surface of lysosomes, the organelles that execute the … Read more