mTOR

Overview of Various Immune Metabolism Signaling Pathways

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Overview of Various Immune Metabolism Signaling Pathways

▉ Abstract T cells receptors, co-stimulation signals, and cytokine signals coordinate the triggering of T cell activation and functional programming through specific signaling networks. Understanding immune metabolism signaling networks regulators and effectors may reveal therapeutic targets for modulating metabolic programs and T cell responses in human diseases. In this article, we summarize the key signaling … Read more

Amino Acids Regulate mTORC1 Activity Through Rag GTPase Dimer

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Amino Acids Regulate mTORC1 Activity Through Rag GTPase Dimer

Actually, I rarely read such purely mechanistic articles, but since mTORC1 is a classic signaling pathway, some newly discovered mechanisms may still be helpful for future explorations. The mTOR signaling pathway is recognized as a target of rapamycin, and my main focus is on adaptive immunity. In recent years, a group of scientists led by … Read more